Last edited by Kagaran
Tuesday, July 7, 2020 | History

2 edition of Studies on pregnancy associated plasma protein-A (PAPP-A) in normal and abnormal pregnancy found in the catalog.

Studies on pregnancy associated plasma protein-A (PAPP-A) in normal and abnormal pregnancy

Jes G. Westergaard

Studies on pregnancy associated plasma protein-A (PAPP-A) in normal and abnormal pregnancy

by Jes G. Westergaard

  • 30 Want to read
  • 31 Currently reading

Published by J.G. Westergaard] in [Odense, Denmark .
Written in English


Edition Notes

StatementJes G. Westergaard.
Classifications
LC ClassificationsMLCS 91/13680 (Q)
The Physical Object
Pagination101 p. ;
Number of Pages101
ID Numbers
Open LibraryOL2133815M
LC Control Number88199192

  The risk prediction of pregnancy-associated plasma protein-A (PAPP-A) for future cardiovascular (CV) events post acute coronary syndrome (ACS) in patients with type-2 diabetes mellitus (T2DM) was investigated in comparison to other risk factors. PAPP-A was measured at hospital admission in consecutive ACS patients ( with T2DM and without).Cited by: 5. Pregnancy-Associated Plasma Protein-A (PAPP-A) is a zinc-binding metalloproteinase protein produced by placental syncytio-trophoblasts and secreted into the maternal circulation where its concentration progressively increases until term. In recent years, PAPP-A has been studied for its potential involvement in cardiovascular (CV) by: 4.

Pregnancy-associated plasma protein-A (PAPP-A) is a protein found in the maternal circulation and is produced by the placenta.. The PAPP-A gene has been assigned to human chromosome 9q and contains 22 exons -A values tend to rise exponentially during pregnancy and the reference range depends on the stage of gestation. The increasing popularity of first-trimester screening to detect aneuploidy 1–7 has as a corollary yielded a range of normal and abnormal values for the analytes and ultrasound measurements used: maternal serum pregnancy-associated protein A (PAPP-A), free β-hCG, and fetal nuchal translucency. The clinical implications of unexplained abnormal values are not well understood.

Abstract. Objectives:To explore the effects of low levels of first trimester Pregnancy Associated Plasma Protein-A (PAPP-A) on adverse pregnancy outcomes. Design: Single centre retrospective observational study. Setting: District general hospital. Population: Women with singleton pregnancies with low PAPP-A, attending Heatherwood and Wexham Park Hospital for first trimester combined screening. Studies suggest that low levels of pregnancy-associated plasma protein A (PAPP-A) in early pregnancy are related to certain complications. These complications can .


Share this book
You might also like
Evaluation of surface water programs.

Evaluation of surface water programs.

Painting in England 1700-1850

Painting in England 1700-1850

Racine school survey, Racine, Wisconsin.

Racine school survey, Racine, Wisconsin.

A letter from the Right Honourable the Lord Inchiqvin, and other the commanders in Munster, to His Majestie

A letter from the Right Honourable the Lord Inchiqvin, and other the commanders in Munster, to His Majestie

Census 80

Census 80

Floating with the dūtakāvyas

Floating with the dūtakāvyas

Finger Lakes Bicyclists Tour Guide

Finger Lakes Bicyclists Tour Guide

coloured dome

coloured dome

How nonviolence protects the state

How nonviolence protects the state

Reflections on cross-cultural familial antecedents of dogmatism.

Reflections on cross-cultural familial antecedents of dogmatism.

Anápolis, Brazil

Anápolis, Brazil

Etching & etchers.

Etching & etchers.

Convention of association between the European Economic Community and the African and Malagasy states associated with that community and annexed documents.

Convention of association between the European Economic Community and the African and Malagasy states associated with that community and annexed documents.

Studies on pregnancy associated plasma protein-A (PAPP-A) in normal and abnormal pregnancy by Jes G. Westergaard Download PDF EPUB FB2

Summary The plasma concentration of pregnancy‐associated plasma protein A (PAPP‐A) was measured in 34 women during the last 10 weeks of pregnancy.

From 30 to 36 weeks the concentration of this protein increased steadily. Thereafter the concentration of PAPP‐A rose more steeply, the highest amounts being found in early by: Pregnancy-associated Plasma Protein A (PAPP-A) test, otherwise, known as the double marker test, is usually done before the 14 Weeks of gestation.

It helps in early identification of foetuses at high risk of trisom 13 and nancy. A number of studies have related maternal circulating concentrations of pregnancy-associated plasma protein A (PAPP-A), a trophoblast derived protease for IGF binding proteins 4 and 5, to eventual perinatal outcome.

These studies have shown that low levels of PAPP-A are associated. The serum markers used for FTAS are pregnancy-associated plasma protein A (PAPP-A) and beta human chorionic gonadotropin.

In the present study, we aimed to assess the role of PAPP-A. Research has demonstrated that pregnancy-associated plasma protein A (PAPP-A) plays a role in cardiovascular disease, as evidenced by the association between PAPP-A and severity of heart damage.

Trophoblast-derived pregnancy-associated plasma protein A (PAPPA) is specifically elevated in pregnant women serum, and is known to promote trophoblast cell proliferation and adhesion. However, the Cited by: 4. To evaluate the 48‐hour release of pregnancy‐associated plasma protein A (PAPP‐A) and its association with 12‐month outcome in patients with acute ST‐elevation myocardial infarction (STEMI).

Methods. Sixty‐two consecutive STEMI patients were included (40 men and 22 women, median age years (range 34–84)), of whom 54 (% Cited by: nancy-associated plasma protein A (PAPP-A), which is a routine indicator used for Down syndrome (DS) screening.

The added utility of this biomark er with respect to predicting GDM came at no extra cost. PAPP-A is produced by the syncytiotrophoblast, and is maintained at high concentrations in the circulation and pla-centa during by: 4. Pregnancy-associated plasma protein A (PAPP-A) to predict adverse fetal outcomes in Chinese: What is the optimal cutoff value.

Journal of Obstetrics Cited by: 4. Qin QP, Kokkala S, Lund J, Tamm N, Qin X, Lepäntalo M, Pettersson K () Immunoassays developed for pregnancy-associated plasma protein-A (PAPP-A) in pregnancy may not recognize PAPP-A in acute coronary syndromes.

Clin Chem 52(3)– CrossRef PubMed Google Scholar. Pregnancy-associated plasma protein-A2 (PAPP-A2), a metalloproteinase purportedly related to pregnancy, foetal growth and development, has Author: Astrid Steinbrecher, Jürgen Janke, Matthew N.

Poy, Claus Oxvig, Tobias Pischon. CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Pregnancy-associated plasma protein A (PAPP-A) is an important pregnancy protein.

PAPP-A exists in pregnancy serum as a heterotetrameric complex with the proform of eosinophil major basic protein (proMBP), forming an approximately kDa and called PAPP-A/proMBP. This study sought to investigate whether pregnancy-associated plasma protein-A (PAPP-A) is useful for risk assessment in non–ST-segment elevation acute coronary syndrome (NSTE-ACS).

Abstract. The placenta secretes a wide range of steroid and protein molecules into the maternal circulation. The steroids include such molecules as oestriol, and the proteins include enzymes such as heat-stable alkaline phosphatase, hormones such as placental lactogen, and a group of proteins including pregnancy associated plasma protein A (PAPP-A), which as yet have no described function by: Among other maternal serum biochemical markers, FTS and IPS in Canada both measure pregnancy-associated plasma protein A (PAPP-A) levels in the first trimester.

1 Pregnancy-associated plasma protein A is a protease that participates in the local release of insulinlike growth by: The aim is to provide an overall view of the association of low pregnancy-associated plasma protein A (PAPP-A) levels with adverse perinatal outcomes. The available literature in PubMed/Medline regarding PAPP-A and adverse pregnancy outcomes was searched for related articles, including terms such as “PAPP-A,” “intrauterine growth restriction (IUGR),” “small for gestational age (SGA Author: Panagiotis Antsaklis, Zacharias Fasoulakis, Marianna Theodora, Michail Diakosavvas, Emmanuel N Konto.

Pregnancy-associated plasma protein A (PAPP-A) is a peptidase produced by syncitiotrophoblast with hydrolytic activity for insulin-like growth factor binding proteins. 90,91 These regulate insulin growth factors known to be important for implantation, for trophoblast invasion of maternal decidua and for placental growth.

92 It is released into the maternal circulation where it binds the eosinophil major. pregnancy-associated plasma protein A (PAPP-A) levels in the first trimester.1 Pregnancy-associated plasma pro-tein A is a protease that participates in the local release of insulinlike growth factors.

Since the mids the estab-lished association of low levels of PAPP-A with Down syndrome has led to wide use of PAPP-A measurementCited by:   In this issue of the Journal, Mueller et al. (9) report that plasma concentrations of pregnancy-associated plasma protein-A (PAPP-A) are higher in patients with symptomatic peripheral atherosclerotic disease (PAD) than in patients without atherosclerotic disease.

Does pregnancy-associated plasma protein-A (PAPP-A) predict risk for non–ST-segment elevation acute coronary syndrome (NSTE-ACS). Methods: Patients used for this study were enrolled in the MERLIN–TIMI 36 (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST Elevation Acute Coronary Syndromes) trial.

Malene R. Jepsen, Søren Kløverpris, Jane A. Bøtkjær, Marie L. Wissing, Claus Y. Andersen, Claus Oxvig, The proteolytic activity of pregnancy-associated plasma protein-A is potentially regulated by stanniocalcin-1 and -2 during human ovarian follicle development, Human Reproduction, Vol Issue 4, AprilPages –, https Cited by: Start studying Chpt 53 study guide (Bonus).

Learn vocabulary, terms, and more with flashcards, games, and other study tools.The aim of this study was to assess if women with a low first trimester maternal pregnancy-associated plasma protein-A (PAPP-A) level are at increased risk of emergency cesarean (EmCS) for intrapartum fetal compromise (IFC) and/or adverse neonatal outcomes.

This was a retrospective cohort study performed at Mater Mother’s Hospital, Brisbane, Australia, between and